Journal article
Oxidized LDL and AGE-LDL in circulating immune complexes strongly predict progression of carotid artery IMT in type 1 diabetes
KJ Hunt, N Baker, P Cleary, JY Backlund, T Lyons, A Jenkins, G Virella, MF Lopes-Virella
Atherosclerosis | ELSEVIER IRELAND LTD | Published : 2013
Abstract
Objective: Over 90% of modified LDL in circulation is associated to specific antibodies circulating as part of immune complexes (IC); however, few studies have examined their relationship with cardiovascular disease. Methods: We report the relationship between circulating concentrations of IC of oxidized LDL (oxLDL-IC), malondialdehyde-LDL (MDA-LDL-IC) and advanced glycation end products-LDL (AGE-LDL-IC) and progression of atherosclerosis over a 12 year period in 467 individuals with type 1 diabetes who participated in the Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) study. OxLDL-IC, AGE-LDL-IC and MDA-LDL-IC levels w..
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Awarded by National Heart, Lung, and Blood Institute
Funding Acknowledgements
This work was supported by a Program Project funded by the National Institutes of Health/NHLBI (PO1 HL 55782), by two R01 Grants funded by NIH/NIDDK (R01 DK081352 and R01 DK088778) and by a Juvenile Diabetes Foundation Grant (2006-49). The work was also supported by the Research Service of the Ralph H. Johnson Department of Veterans Affairs Medical Center. The views expressed in this article are those of the authors and do not necessarily reflect the position or policy of the Department of Veterans Affairs or the United States government.