Journal article
Coupling blood flow and neural function in the retina: a model for homeostatic responses to ocular perfusion pressure challenge
Zheng He, Jeremiah KH Lim, Christine TO Nguyen, Algis J Vingrys, Bang V Bui
PHYSIOLOGICAL REPORTS | WILEY | Published : 2013
DOI: 10.1002/phy2.55
Abstract
Retinal function is known to be more resistant than blood flow to acute reduction of ocular perfusion pressure (OPP). To understand the mechanisms underlying the disconnect between blood flow and neural function, a mathematical model is developed in this study, which proposes that increased oxygen extraction ratio compensates for relative ischemia to sustain retinal function. In addition, the model incorporates a term to account for a pressure-related mechanical stress on neurons when OPP reduction is achieved by intraocular pressure (IOP) elevation. We show that this model, combining ocular blood flow, oxygen extraction ratio, and IOP mechanical stress on neurons, accounts for retinal funct..
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Grants
Awarded by National Health and Medical Research Council of the Australian government
Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by grants from the National Health and Medical Research Council of the Australian government (BVB & AJV 566570, 566579) and the Australian Research Council Linkage Project (CTON, BVB & AJV LP100200129).