Journal article
Characterization of an ntrX Mutant of Neisseria gonorrhoeae Reveals a Response Regulator That Controls Expression of Respiratory Enzymes in Oxidase-Positive Proteobacteria
John M Atack, Yogitha N Srikhanta, Karrera Y Djoko, Jessica P Welch, Norain HM Hasri, Christopher T Steichen, Rachel N Vanden Hoven, Sean M Grimmond, Dk Seti Maimonah Pg Othman, Ulrike Kappler, Michael A Apicella, Michael P Jennings, Jennifer L Edwards, Alastair G McEwan
JOURNAL OF BACTERIOLOGY | AMER SOC MICROBIOLOGY | Published : 2013
DOI: 10.1128/JB.02062-12
Abstract
NtrYX is a sensor-histidine kinase/response regulator two-component system that has had limited characterization in a small number of Alphaproteobacteria. Phylogenetic analysis of the response regulator NtrX showed that this two-component system is extensively distributed across the bacterial domain, and it is present in a variety of Betaproteobacteria, including the human pathogen Neisseria gonorrhoeae. Microarray analysis revealed that the expression of several components of the respiratory chain was reduced in an N. gonorrhoeae ntrX mutant compared to that in the isogenic wild-type (WT) strain 1291. These included the cytochrome c oxidase subunit (ccoP), nitrite reductase (aniA), and nitr..
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Awarded by NH MRC
Funding Acknowledgements
This work was supported by NH & MRC Program grants 284214 and 565526 to A.G.M. and M.P.J. J.P.W. was a recipient of an Australian Postgraduate Award.