Journal article

Oral aphthous-like lesions, PFAPA syndrome: a review.

Felice Femiano, Alessandro Lanza, Curzio Buonaiuto, Fernando Gombos, Nicola Cirillo

J Oral Pathol Med | Published : 2008


Aphthous ulcers are the most common oral mucosal lesions in the general population. Several precipitating factors for aphthous ulcers are suggested to operate on subjects with genetic predisposition. Sometimes aphthous ulcers can be the sign of systemic diseases. Therefore, it is essential to establish a correct diagnosis to determine suitable therapy. There are several diseases potentially responsible for oral ulcers. Sometimes appearance of periodic oral ulcers coincides with periodic fever and other symptoms leading to the diagnosis of a rare childhood disease: PFAPA (periodic fever, aphthous stomatitis, pharyngitis and adenopathy) syndrome. PFAPA or Marshall's syndrome is characterized b..

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University of Melbourne Researchers