Journal article
Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways
I Ballesteros, MI Cuartero, JM Pradillo, J de la Parra, A Pérez-Ruiz, A Corbí, M Ricote, JA Hamilton, M Sobrado, J Vivancos, F Nombela, I Lizasoain, MA Moro
Journal of Leukocyte Biology | FEDERATION AMER SOC EXP BIOL | Published : 2014
DOI: 10.1189/jlb.0613326
Abstract
PPARγ-achieved neuroprotection in experimental stroke has been explained by the inhibition of inflammatory genes, an action in which 5-LO, Alox5, is involved. In addition, PPARγ is known to promote the expression of CD36, a scavenger receptor that binds lipoproteins and mediates bacterial recognition and also phagocytosis. As phagocytic clearance of neutrophils is a requisite for resolution of the inflammatory response, PPARγ-induced CD36 expression might help to limit inflammatory tissue injury in stroke, an effect in which 5-LO might also be involved. Homogenates, sections, and cellular suspensions were prepared from brains of WT and Alox5-/- mice exposed to distal pMCAO. BMMs were obtaine..
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Awarded by Spanish Ministry of Economy and Competitiveness
Awarded by Fondo Europeo de Desarrollo Regional (FEDER) "Instituto de Salud Carlos III" RETICS
Awarded by local government of Madrid
Funding Acknowledgements
This work was supported by grants from the Spanish Ministry of Economy and Competitiveness CSD2010-00045 (to M. A. M.), SAF2009-08145 and SAF2012-33216 (to M. A. M.), SAF2011-23354 (to I. L.), SAF2009-07466 and SAF2012-31483 (to M. R.), from Fondo Europeo de Desarrollo Regional (FEDER) "Instituto de Salud Carlos III" RETICS RD12/0014/0003 (to I. L.) and from the local government of Madrid S2010/BMD-2336 (to M. A. M.) and S2010/BMD-2349 (to I. L.). I. B. and M. I. C. are fellows of the Spanish Ministry of Economy and Competitiveness. The authors thank Tamara Atanes and Roberto Canadas for their technical assistance.