Journal article

Nuclear receptor NR4A1 promotes breast cancer invasion and metastasis by activating TGF-beta signalling

FangFang Zhou, Yvette Drabsch, Tim JA Dekker, Amaya Garcia de Vinuesa, Yihao Li, Lukas JAC Hawinkels, Kelly-Ann Sheppard, Marie-Jose Goumans, Rodney B Luwor, Carlie J de Vries, Wilma E Mesker, Rob AEM Tollenaar, Peter Devilee, Chris X Lu, Hongjian Zhu, Long Zhang, Peter ten Dijke

Nature Communications | NATURE PUBLISHING GROUP | Published : 2014


Awarded by Netherlands organization for scientific research

Awarded by Bas Mulder Award

Funding Acknowledgements

We are grateful to our colleagues for helpful discussions. We thank Martijn Rabelink for providing shRNA lenti constructs, Craig Mickanin for high-throughput screening of short interfering RNAs and expression constructs, Patricia Olofson for help with bioluminescent imaging, Maarten van Dinther and Midory Thorikay for expert technical assistance, and Kohei Miyazono and Shengcai Lin for reagents. This work was supported by grants from the Netherlands organization for scientific research (VICI 016.066.606), Cancer Genomics Centre Netherlands and Centre for Biomedical Genetics to P.t.D. and Bas Mulder Award 2011 (UL2011 5051) to L.J.A.C.H. This work was supported by Key Construction Program of the National '985' Project and Zhejiang University Special Fund for Fundamental Research, as well as the Fundamental Research Funds for the Central Universities.