Central injection of relaxin-3 receptor (RXFP3) antagonist peptides reduces motivated food seeking and consumption in C57BL/6J mice
Craig M Smith, Berenice E Chua, Cary Zhang, Andrew W Walker, Mouna Haidar, David Hawkes, Fazel Shabanpoor, Mohammad Akhter Hossain, John D Wade, K Johan Rosengren, Andrew L Gundlach
BEHAVIOURAL BRAIN RESEARCH | ELSEVIER | Published : 2014
Behavioural arousal in mammals is regulated by various interacting central monoamine- and peptide-neurotransmitter/receptor systems, which function to maintain awake, alert and active states required for performance of goal-directed activities essential for survival, including food seeking. Existing anatomical and functional evidence suggests the highly-conserved neuropeptide, relaxin-3, which signals via its cognate Gi/o-protein coupled receptor, RXFP3, contributes to behavioural arousal and feeding behaviour in rodents. In studies to investigate this possibility further, adult male C57BL/6J mice were treated with the selective RXFP3 antagonist peptides, R3(B1-22)R/I5(A) and R3(B1-22)R, and..View full abstract
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Awarded by National Health and Medical Research Council (Australia)
This research was supported by National Health and Medical Research Council (Australia) project grants 509246 and 1024885 (A.L.G.) and 508995 (J.D.W.), and by the Pratt and Besen Family Foundations (A.L.G.) and the Victorian Government Operational Infrastructure Support Program. J.D.W. and A.L.G. are NHMRC (Australia) Fellows. C.Z. is the recipient of a Bethlehem Griffiths Research Foundation Scholarship, and A.W.W. is the recipient of a University of Melbourne International Scholarship (MIFRS/MIRS). We thank Steven Sutton and Timothy Lovenberg (Janssen Research and Development LLC, San Diego, USA) for providing the original colony of relaxin-3 MO mice.