Journal article
Curated microRNAs in urine and blood fail to validate as predictive biomarkers for high-risk prostate cancer
N Sapre, MKH Hong, G Macintyre, H Lewis, A Kowalczyk, AJ Costello, NM Corcoran, CM Hovens
Plos One | Published : 2014
Abstract
Purpose: The purpose of this study was to determine if microRNA profiling of urine and plasma at radical prostatectomy can distinguish potentially lethal from indolent prostate cancer. Materials and Methods: A panel of microRNAs was profiled in the plasma of 70 patients and the urine of 33 patients collected prior to radical prostatectomy. Expression of microRNAs was correlated to the clinical endpoints at a follow-up time of 3.9 years to identify microRNAs that may predict clinical response after radical prostatectomy. A machine learning approach was applied to test the predictive ability of all microRNAs profiled in urine, plasma, and a combination of both, and global performance assessed ..
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Funding Acknowledgements
NS is supported by postgraduate scholarships from the Cancer Council Victoria, Cybec Foundation and Royal Australasian College of Surgeons. This study was supported by funding from the Australian Government to the Australian Prostate Cancer Research Epworth. AK and GM are supported by NICTA. NICTA is funded by the Australian Government as represented by the Department of Broadband, Communications and the Digital Economy and the Australian Research Council through the ICT Centre of Excellence program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.