Journal article

The Clinical Relevance of Pathologic Subtypes in Metastatic Lung Adenocarcinoma

Timothy D Clay, Hongdo Do, Vijaya Sundararajan, Melissa M Moore, Matthew Conron, Gavin M Wright, Sue-Anne McLachlan, Alexander Dobrovic, Prudence A Russell

JOURNAL OF THORACIC ONCOLOGY | ELSEVIER SCIENCE INC | Published : 2014

Abstract

INTRODUCTION: The International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification of lung adenocarcinoma recommends identification of pathologic patterns in metastatic samples where possible. We investigated the clinical relevance of these patterns. METHODS: Patients with a surgical biopsy of lung adenocarcinoma from a metastatic site were included. Slides were reviewed by an anatomical pathologist identifying the histologic patterns of solid with mucin, acinar, micropapillary, papillary, and assigning a major adenocarcinoma subtype according to the International Association for the Study of Lung Cancer/American Thoracic Society/Eu..

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Grants

Awarded by National Health and Medical Research Council


Funding Acknowledgements

T.D.C. has received support to attend the World Conference on Lung Cancer 2013 from Boehringer Ingelheim. H. D. has received a Postdoctoral Cancer Research Fellowship from the Cancer Council of Victoria. V. S. reports her institution received funding to pay for statistical advice related to this manuscript and has provided consultancy services to the Victorian Department of Health. M. M. M. received a grant from the St. Vincent's Hospital research endowment fund. G. M. W. reports his institution receives funding from Covidien for educational presentations, his institution has previously received a grant from Covidien, and he has previously received funding for meeting expenses from Karl Storz. Funding for this study was provided by St. Vincent's Hospital research endowment fund. T. D. C. was supported by Australian Postgraduate Award from the University of Melbourne. G. M. W. was supported by National Health and Medical Research Council Scholarship GNT 1038699 and University of Melbourne Medical Postgraduate Committee Gordon-Taylor Scholarship. All other authors declare no conflict of interest.