Journal article
SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease
LH Chen, SL Advani, K Thai, M Golam Kabir, MM Sood, IW Gibson, DA Yuen, KA Connelly, PA Marsden, DJ Kelly, RE Gilbert, A Advani
Plos One | Published : 2014
Open access
Abstract
The progressive decline of renal function in chronic kidney disease (CKD) is characterized by both disruption of the microvascular architecture and the accumulation of fibrotic matrix. One angiogenic pathway recently identified as playing an essential role in renal vascular development is the stromal cell-derived factor-1a (SDF-1)/CXCR4 pathway. Because similar developmental processes may be recapitulated in the disease setting, we hypothesized that the SDF-1/CXCR4 system would regulate microvascular health in CKD. Expression of CXCR4 was observed to be increased in the kidneys of subtotally nephrectomized (SNx) rats and in biopsies from patients with secondary focal segmental glomeruloscler..
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Awarded by CIHR
Awarded by Canadian Diabetes Association (CDA)
Funding Acknowledgements
These studies were supported by grants from CIHR (grant MOP-97791) and the Canadian Diabetes Association (CDA, OG-3-10-2949-AA) to Dr. Advani. Mr. Chen was supported by a CIHR Frederick Banting and Charles Best Graduate Scholarship and a Banting and Best Diabetes Centre Graduate Studentship. Dr. Advani is a Canadian Diabetes Association Clinician Scientist and this work was supported, in part, by the Canadian Diabetes Association. Dr. Gilbert is a Canada Research Chair in Diabetes Complications. Dr. Yuen is a KRESCENT New Investigator and Canadian Diabetes Association Clinician Scientist. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.