Journal article

The maturation of antibody technology for the HIV epidemic

Wendy R Winnall, Matthew D Beasley, Rob J Center, Matthew S Parsons, Ben R Kiefel, Stephen J Kent

IMMUNOLOGY AND CELL BIOLOGY | NATURE PUBLISHING GROUP | Published : 2014

Abstract

Antibodies are one of our most useful biological tools. Indeed, improvements in antibody-based technologies have ushered in a new era of antibody-based therapeutics, research and diagnostic tools. Although improved technologies have led to the development of therapeutic antibodies for treatment of malignancies and inflammatory conditions, the use of advanced antibody technology in the therapy of viral infections is in its infancy. Non-human primate studies have demonstrated that antibodies against the HIV envelope can both prevent viral infection and control viremia. Despite the obvious potential of antibody therapies against HIV, there remain limitations in production and purification capac..

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