RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard; Joanne A O'Donnell; Joseph M Evans; Najoua Lalaoui; Ashleigh R Poh; TeWhiti Rogers; James E Vince; Kate E Lawlor; Robert L Ninnis; Holly Anderton; Cathrine Hall; Sukhdeep K Spall; Toby J Phesse; Helen E Abud; Louise H Cengia; Jason Corbin; Sandra Mifsud; Ladina Di Rago; Donald Metcalf; Matthias Ernst; Grant Dewson; Andrew W Roberts; Warren S Alexander; James M Murphy; Paul G Ekert; Seth L Masters; David L Vaux; Ben A Croker; Motti Gerlic; John Silke

Journal article

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst Show all

Cell | CELL PRESS | Published : 2014

DOI: 10.1016/j.cell.2014.04.019

University of Melbourne Researchers

Kate Lawlor Author Medical Biology (W.E.H.I.)

David Vaux Author Medical Biology (W.E.H.I.)

Najoua Lalaoui Author Medical Biology (W.E.H.I.)

James Vince Author Medical Biology (W.E.H.I.)

James Murphy Author Medical Biology (W.E.H.I.)

Grants

Awarded by NHMRC

Awarded by NHMRC fellowships

Awarded by NHMRC IRIISS grant

Funding Acknowledgements

We thank staff in the WEHI Bioservices facility, Vishva Dixit for Ripk3-/- mice, Michelle Kelliher for Ripk1-/- mice, Heinrich Korner for Tnf-/- and Tnfr1-/- mice, Stephen Hedrick for Casp8fl/fl mice, and Anne Voss for helpful discussions. This work was supported by NHMRC grants (1016647, 461221, 1016701, 1025594, 1046984, 1046010, 1025239, 637367, 1008131, and 1057905), an Australian Research Council Fellowship (B.A.C.), an APA scholarship (J.A.R.), a Dora Lush Scholarship (J.A.O.), a La Trobe University Postgraduate Research Scholarship (J.M. E.), a VESKI innovation fellowship (S.L.M.), ARC Fellowship (J.M. M.), Cancer Council Victoria Carden Fellowship (D.M.), and NHMRC fellowships to J.S., W.S.A., and A.W.R. (541901, 1058344, and 637309) with additional support from the Australian Cancer Research Fund, Victorian State Government Operational Infrastructure Support, and an NHMRC IRIISS grant (361646).