Lower cortical serotonin 2A receptors in major depressive disorder, suicide and in rats after administration of imipramine
Brian Dean, Nahed Tawadros, Myoung Suk Seo, Won Je Jeon, Ian Everall, Elizabeth Scarr, Andrew Gibbons
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY | OXFORD UNIV PRESS | Published : 2014
We have attempted to replicate studies showing higher levels of serotonin 2A receptors (HTR2A) in the cortex of people with mood disorders and to determine the effects of treating rats with antidepressant drugs on levels of that receptor. In situ [3H]ketanserin binding and autoradiography was used to measure levels of HTR2A in Brodmann's area (BA) 46 and 24 from people with major depressive disorders (MDD, n = 16), bipolar disorders (BD, n = 14) and healthy controls (n = 14) as well as the central nervous system (CNS) of rats (20 per treatment arm) treated for 10 or 28 d with fluoxetine (10 mg/kg/d) or imipramine (20 mg/kg/d). Compared with controls, HTR2A were lower in BA 24, but not BA 46,..View full abstract
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Awarded by NHMRC
BD is an NHMRC Senior Research Fellow (APP1002240) and ES is an ARC Future Fellow (FT100100689). This work was supported in part by NHMRC project grant (APP628699), the Victorian Government's Operational Infrastructure Support and the Rebecca Cooper Medical Research Foundation.