Journal article
The BTB-ZF transcription factor Zbtb20 is driven by Irf4 to promote plasma cell differentiation and longevity
S Chevrier, D Emslie, W Shi, T Kratina, C Wellard, A Karnowski, E Erikci, GK Smyth, K Chowdhury, D Tarlinton, LM Corcoran
Journal of Experimental Medicine | ROCKEFELLER UNIV PRESS | Published : 2014
DOI: 10.1084/jem.20131831
Abstract
The transcriptional network regulating antibody-secreting cell (ASC) differentiation has been extensively studied, but our current understanding is limited. The mechanisms of action of known "master" regulators are still unclear, while the participation of new factors is being revealed. Here, we identify Zbtb20, a Bcl6 homologue, as a novel regulator of late B cell development. Within the B cell lineage, Zbtb20 is specifically expressed in B1 and germinal center B cells and peaks in long-lived bone marrow (BM) ASCs. Unlike Bcl6, an inhibitor of ASC differentiation, ectopic Zbtb20 expression in primary B cells facilitates terminal B cell differentiation to ASCs. In plasma cell lines, Zbtb20 i..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council (NHMRC) Australia (NHMRC IRIISS grant #361646 and Program grant #575500). S. Chevrier is supported by the Swiss National Science Foundation and W. Shi is supported, in part, by NHMRC Project grant #1023454. This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.