Journal article
A prospective study of the prevalence of tuberculosis and bacteraemia in Bangladeshi children with severe malnutrition and pneumonia including an evaluation of Xpert MTB/RIF assay
MJ Chisti, SM Graham, T Duke, T Ahmed, H Ashraf, ASG Faruque, S La Vincente, S Banu, R Raqib, MA Salam
Plos One | Published : 2014
Abstract
Background: Severe malnutrition is a risk factor for pneumonia due to a wide range of pathogens but aetiological data are limited and the role of Mycobacterium tuberculosis is uncertain. Methods: We prospectively investigated severely malnourished young children (<5 years) with radiological pneumonia admitted over a 15-month period. Investigations included blood culture, sputa for microscopy and mycobacterial culture. Xpert MTB/RIF assay was introduced during the study. Study children were followed for 12 weeks following their discharge from the hospital. Results: 405 eligible children were enrolled, with a median age of 10 months. Bacterial pathogens were isolated from blood culture in 18 (..
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Awarded by Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b)
Funding Acknowledgements
This research study was funded by the Dhaka Hospital of International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b; grant no Gr-00233) and its donors, which provide unrestricted support to icddr, b for its operations and research. Current donors providing unrestricted support include: Australian Agency for International Development (AusAID), Government of the People's Republic of Bangladesh, Canadian International Development Agency, Swedish International Development Cooperation Agency, and the Department for International Development, United Kingdom. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.