Journal article

A Bioplex Analysis of Cytokines and Chemokines in First Trimester Maternal Plasma to Screen for Predictors of Miscarriage

Natalie J Hannan, Katerina Bambang, Tu'uhevaha J Kaitu'u-Lino, Justin C Konje, Stephen Tong

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2014

Abstract

BACKGROUND: We have previously shown in two independent cohorts that circulating first trimester Macrophage Inhibitory Cytokine-1 (MIC-1) levels are lower in women in early pregnancy who are destined to miscarriage. While promising, the diagnostic performance of measuring MIC-1 alone was not sufficient for it to be a useful predictive test for miscarriage. Besides MIC-1, there are other cytokines, as well as chemokines, involved in facilitating early pregnancy. We reasoned that screening these factors in maternal plasma could uncover other predictive markers of miscarriage. METHODS: This was a nested case control study, of 78 women from a prospective study of 462 attending the Early Pregnanc..

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Grants

Awarded by Medical Research Council of the United Kingdom


Awarded by National Health and Medical Research Council of Australia


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Funding Acknowledgements

The following funding bodies are acknowledged: The Medical Research Council of the United Kingdom for funding this work (#G0801523 to JCK) and The National Health and Medical Research Council of Australia who provided salary support (#628927 to NJH; #1050765 to ST; #1062418 to TJKL). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.