Journal article
Early detection of ventilation-induced brain injury using magnetic resonance spectroscopy and diffusion tensor imaging: An in vivo study in preterm lambs
B Skiöld, Q Wu, SB Hooper, PG Davis, R McIntyre, M Tolcos, J Pearson, R Vreys, GF Egan, SK Barton, JLY Cheong, GR Polglase
Plos One | Published : 2014
Abstract
Background and Aim: High tidal volume (VT) ventilation during resuscitation of preterm lambs results in brain injury evident histologically within hours after birth. We aimed to investigate whether magnetic resonance spectroscopy (MRS) and/or diffusion tensor imaging (DTI) can be used for early in vivo detection of ventilation-induced brain injury in preterm lambs. Methods: Newborn lambs (0.85 gestation) were stabilized with a "protective ventilation" strategy (PROT, n = 7: prophylactic Curosurf, sustained inflation, VT 7 mL/kg, positive end expiratory pressure (PEEP) 5 cmH2O) or an initial 15 minutes of "injurious ventilation" (INJ, n = 10: VT 12 mL/kg, no PEEP, late Curosurf) followed by P..
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Awarded by National Science Foundation
Funding Acknowledgements
This research was supported by the Swedish Medical Society, the Swedish Brain Foundation, Sallskapet Barnavard, the Rebecca L. Cooper Medical Research Foundation, Monash University Researcher Accelerator Grant, Monash Biomedical Imaging, NH&MRC Research Fellowship (GRP: 1026890), NHMRC Early Career Fellowship (ID 1053787 to JC) and the Victorian Government's Operational Infrastructure Support Program. Chiesi Farmaceutici S. p. A. generously donated the surfactant used in this study. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.