Journal article

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor

Andrew J Brooks, Wei Dai, Megan L O'Mara, Daniel Abankwa, Yash Chhabra, Rebecca A Pelekanos, Olivier Gardon, Kathryn A Tunny, Kristopher M Blucher, Craig J Morton, Michael W Parker, Emma Sierecki, Yann Gambin, Guillermo A Gomez, Kirill Alexandrov, Ian A Wilson, Manolis Doxastakis, Alan E Mark, Michael J Waters

Science | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2014

Grants

Awarded by National Health and Medical Research Council of Australia


Awarded by NSF (USA) Chemical, Bioengineering, Environmental, and Transport Systems Division


Awarded by Div Of Chem, Bioeng, Env, & Transp Sys


Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council of Australia (511120, 1002893, and 102082) and the Australian Research Council to M.J.W., A.J.B, A.E.M., and M.W.P. Infrastructure funding from the Victorian Government to St Vincent's Institute is gratefully acknowledged. W.D. and M.D. acknowledge financial support by the NSF (USA) Chemical, Bioengineering, Environmental, and Transport Systems Division (grant number 1067356) and central processing unit time by the University of Houston Research Computing Center. G.A.G. acknowledges financial support by the Kids Cancer Project of the Oncology Research Foundation. We thank W.A. Johnston for optimizing the Leishmania-based cell-free lysate expression system used in the single-molecule and Alpha screen interaction studies. Confocal imaging was performed at the IMB/ACRF Cancer Biology Imaging Facility, established with the support of the Australian Cancer Research Foundation.