Updating the OMERACT filter: Implications for imaging and soluble biomarkers

MA D'Agostino; M Boers; J Kirwan; D Van Der Heijde; M Østergaard; G Schett; RB Landewé; WP Maksymowych; E Naredo; M Dougados; A Iagnocco; CO Bingham; PM Brooks; DE Beaton; F Gandjbakhch; L Gossec; F Guillemin; SE Hewlett; M Kloppenburg; L March; PJ Mease; I Moller; LS Simon; JA Singh; V Strand; RJ Wakefield; GA Wells; P Tugwell; PG Conaghan

Journal article

Updating the OMERACT filter: Implications for imaging and soluble biomarkers

MA D'Agostino, M Boers, J Kirwan, D Van Der Heijde, M Østergaard, G Schett, RB Landewé, WP Maksymowych, E Naredo, M Dougados, A Iagnocco, CO Bingham, PM Brooks, DE Beaton, F Gandjbakhch, L Gossec, F Guillemin, SE Hewlett, M Kloppenburg, L March Show all

Journal of Rheumatology | J RHEUMATOL PUBL CO | Published : 2014

DOI: 10.3899/jrheum.131313

Abstract

Objective. The Outcome Measures in Rheumatology (OMERACT) Filter provides a framework for the validation of outcome measures for use in rheumatology clinical research. However, imaging and biochemical measures may face additional validation challenges because of their technical nature. The Imaging and Soluble Biomarker Session at OMERACT 11 aimed to provide a guide for the iterative development of an imaging or biochemical measurement instrument so it can be used in therapeutic assessment. Methods. A hierarchical structure was proposed, reflecting 3 dimensions needed for validating an imaging or biochemical measurement instrument: outcome domain(s), study setting, and performance of the inst..

View full abstract