VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum

C Fung; P Unterweger; LJ Parry; JC Bornstein; JPP Foong

Journal article

VPAC1 receptors regulate intestinal secretion and muscle contractility by activating cholinergic neurons in guinea pig jejunum

C Fung, P Unterweger, LJ Parry, JC Bornstein, JPP Foong

American Journal of Physiology Gastrointestinal and Liver Physiology | AMER PHYSIOLOGICAL SOC | Published : 2014

DOI: 10.1152/ajpgi.00416.2013

Abstract

In the gastrointestinal tract, vasoactive intestinal peptide (VIP) is found exclusively within neurons. VIP regulates intestinal motility via neurally mediated and direct actions on smooth muscle and secretion by a direct mucosal action, and via actions on submucosal neurons. VIP acts via VPAC1 and VPAC2 receptors; however, the subtype involved in its neural actions is unclear. The neural roles of VIP and VPAC1 receptors (VPAC1R) were investigated in intestinal motility and secretion in guinea pig jejunum. Expression of VIP receptors across the jejunal layers was examined using RT-PCR. Submucosal and myenteric neurons expressing VIP receptor subtype VPAC1 and/or various neurochemical markers..

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University of Melbourne Researchers

Joel Bornstein Author

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Grants

Awarded by National Health and Medical Research Council Australia

Funding Acknowledgements

The study was supported by a grant from the National Health and Medical Research Council Australia (Grant No. APP1006453). C. Fung is supported by an Australian Postgraduate Award.