Journal article
Heparin-induced thrombocytopenia in the critically ill: Interpreting the 4Ts test in a randomized trial
M Crowther, D Cook, G Guyatt, N Zytaruk, E McDonald, D Williamson, M Albert, P Dodek, S Finfer, S Vallance, D Heels-Ansdell, L McIntyre, S Mehta, F Lamontagne, J Muscedere, M Jacka, O Lesur, J Kutsiogiannis, J Friedrich, JR Klinger Show all
Journal of Critical Care | Published : 2014
Abstract
Background: Thrombocytopenia occurs in 20% to 45% of critically ill medical-surgical patients. The 4Ts heparin-induced thrombocytopenia (HIT) score (with 4 domains: Thrombocytopenia, Timing of thrombocytopenia, Thrombosis and o. Ther reason[s] for thrombocytopenia) might reliably identify patients at low risk for HIT. Interobserver agreement on 4Ts scoring is uncertain in this setting. Objective: To evaluate whether a published clinical prediction rule (the "4Ts score") reliably rules out HIT in "low-risk" intensive care unit (ICU) patients as assessed by research coordinators (who prospectively scored) and 2 adjudicators (who scored retrospectively) during an international heparin thrombopr..
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Funding Acknowledgements
We are grateful to PROTECT collaborators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. We thank Suzanne Duchesne and Katherine Krolicki for their assistance in managing the HITEC Study. HITEC was funded by the Heart and Stroke Foundation of Canada. M. Crowther holds a Career Investigator award from the Heart and Stroke Foundation and also holds the Leo Pharma Chair in Thromboembolism Research at McMaster University. D. Cook is a Research Chair of the Canadian Institutes of Health Research.