Journal article
Comparison of the serum lipidome in patients with abdominal aortic aneurysm and peripheral artery disease
JV Moxon, D Liu, G Wong, JM Weir, R Behl-Gilhotra, B Bradshaw, BA Kingwell, PJ Meikle, J Golledge
Circulation Cardiovascular Genetics | Published : 2014
Abstract
Background: Currently, the relationship between circulating lipids and abdominal aortic aneurysm (AAA) is unclear. We conducted a lipidomic analysis to identify serum lipids associated with AAA presence. Secondary analyses assessed the ability of models incorporating lipidomic features to improve stratification of patient groups with and without AAA beyond traditional risk factors. Methods and Results: Serum lipids were profiled via liquid chromatography tandem mass spectrometry analysis of serum from 161 patients with AAA and 168 controls with peripheral artery disease. Binary logistic regression was used to identify AAA-associated lipids. Classification models were created based on a combi..
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Funding Acknowledgements
We thank Cedric Hensman for technical support. This work was supported by a National and International Research Alliances Program grant from the Queensland Government, grants from the James Cook University School of Medicine and Dentistry, the National Health and Medical Research Council (NHMRC), and the Operational Infrastructure support scheme from the Victorian State Government, Australia. We also thank the Queensland Tropical Health Alliance for infrastructure support. Prof Golledge holds a Practitioner Fellowship from the National Health and Medical Research Council, Australia and a Senior Clinical Research Fellowship from the Queensland Government. Prof Meikle is a NHMRC Senior Research Fellow, and Prof Kingwell a NHMRC Principal Research Fellow.