G-protein β3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees

CA Bousman; M Potiriadis; IP Everall; JM Gunn

Journal article

G-protein β3 subunit genetic variation moderates five-year depressive symptom trajectories of primary care attendees

CA Bousman, M Potiriadis, IP Everall, JM Gunn

Journal of Affective Disorders | ELSEVIER SCIENCE BV | Published : 2014

DOI: 10.1016/j.jad.2014.04.044

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Abstract

Background Genetic variation in the G-protein β3 subunit (GNB3) has previously been associated with gene splicing that has been further linked to increased signal transduction and major depressive disorder. However, the effect of GNB3 genetic variation on depressive symptom trajectories is currently unknown. The aim of the present study is to examine whether genetic variation in GNB3 moderates depressive symptom trajectories among 301 primary care attendees enrolled in the Diagnosis, Management and Outcomes of Depression in Primary Care (diamond) prospective cohort study. Methods Depressive symptoms were assessed using three measures: (1) DSM-IV criteria, (2) Primary Care Evaluation of Menta..

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University of Melbourne Researchers

Jane Gunn Author

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The diamond cohort study - long term outcomes of depressive

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Grants

Awarded by National Institute on Drug Abuse

Funding Acknowledgements

The diamond study is funded by the National Health and Medical Research Council (IDs 299869, 454463, 566511 and 1002908) and the Victorian Centre for Excellence in Depression and Related Disorders, an initiative between beyondblue and the Victorian Government. The collection of DNA and genotyping was funded by the LEW Carty Chartable Fund (ID 7284). No funding body had a role in the study design, the collection, analysis, and interpretation of data, or the writing of the manuscript for publication. We acknowledge the 30 dedicated GPs, their patients and practice staff for making this research possible. We thank the diamond project team, including associate investigators and researchers involved in the diamond study: Ms. Aves Middleton, Ms. Konstancja Densley, Professor Helen Herrman, Professor Christopher Dowrick, Dr. Gursharan Chana and casual research staff.