Journal article
A signature predicting poor prognosis in gastric and ovarian cancer represents a coordinated macrophage and stromal response
RA Busuttil, J George, RW Tothill, K Ioculano, A Kowalczyk, C Mitchell, S Lade, P Tan, I Haviv, A Boussioutas
Clinical Cancer Research | AMER ASSOC CANCER RESEARCH | Published : 2014
Abstract
Purpose: Gene-expression profiling has revolutionized the way we think about cancer and confers the ability to observe the synchronous expression of thousands of genes. The use of putative genome-level expression profiles has allowed biologists to observe the complex interactions of genes that constitute recognized biologic pathways. We used gastric and ovarian datasets to identify gene-expression signatures and determine any functional significance. Experimental Design: Microarray data of 94-tumor and 45-benign samples derived from patients with gastric cancer were interrogated using Hierarchical Ordered Partitioning and Collapsing Hybrid analysis identifying clusters of coexpressed genes. ..
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Awarded by NHMRC
Funding Acknowledgements
This work was supported by the NHMRC (grant 288714), A. Kowalczyk was financially supported by National ICT Australia (NICTA), which is funded by the Australian Government through the Department of Communications and the Australian Research Council through the ICT Centre of Excellence Program.