Journal article
Infection-induced inflammation and cerebral injury in preterm infants
T Strunk, T Inder, X Wang, D Burgner, C Mallard, O Levy
Lancet Infectious Diseases | Published : 2014
Abstract
Preterm birth and infectious diseases are the most common causes of neonatal and early childhood deaths worldwide. The rates of preterm birth have increased over recent decades and account for 11% of all births worldwide. Preterm infants are at significant risk of severe infection in early life and throughout childhood. Bacteraemia, inflammation, or both during the neonatal period in preterm infants is associated with adverse outcomes, including death, chronic lung disease, and neurodevelopmental impairment. Recent studies suggest that bacteraemia could trigger cerebral injury even without penetration of viable bacteria into the CNS. Here we review available evidence that supports the concep..
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Funding Acknowledgements
Ohs laboratory is funded by the National Institutes of Health R01-AI100135-01 and by the Bill & Melinda Gates Foundation Global Health Grants OPPGH5284 and OPP1035192. OL is an inventor on a patent for the use of recombinant bactericidal/permability-increasing protein (rBPI) in radiation injury. DB is supported by a National Health and Medical Research Council of Australia Career Development Fellowship (572504). XW is supported by grants from the Swedish Medical Research Council (VR K2009-54X-21119-01-4), VINNMER-Marie Curie international qualification (VINNOVA, 2011-03458), and Bill & Melinda Gates Foundation-Grand Challenges Explorations (OPP1036135). CM's research is supported by the Swedish Medical Research Council (VR2012-2992), government grant in Public Health Service at the Sahlgrenska University Hospital (ALFGBG-142881), European Union grant FP7 (Neurobid, HEALTHF2-2009-241778), the Leducq foundation (DSRR_P34404), Ahlen Foundation, and the Swedish Brain Foundation (FO2013-095). TI is supported by the Doris Duke Charitable Foundation and the National Institutes of Health.