Journal article

The effect of amygdala kindling on neuronal firing patterns in the lateral thalamus in the GAERS model of absence epilepsy

Nihan Carcak, Thomas Zheng, Idrish Ali, Ahmad Abdullah, Chris French, Kim L Powell, Nigel C Jones, Leena van Raay, Gil Rind, Filiz Onat, Terence J O'Brien

EPILEPSIA | WILEY | Published : 2014

Abstract

OBJECTIVE: The co-occurrence of absence and mesial temporal lobe epilepsy is rare in both humans and animal models. Consistent with this, rat models of absence epilepsy, including genetic absence epilepsy rats from Strasbourg (GAERS), are resistant to experimental temporal lobe epileptogenesis, in particular by amygdala kindling. Structures within the cortical-thalamocortical system are critically involved in the generation and maintenance of the electrographic spike-and-wave discharges (SWDs) that characterize absence seizures. Using in vivo electrophysiologic recordings, this study investigated the role of thalamocortical circuitry in the generalization of amygdala-kindling induced seizure..

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Grants

Awarded by NHMRC


Funding Acknowledgements

We thank Professor Vincenzo Crunelli for his critical review and helpful advice. This study was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) under the 2214-International Research Fellowship Programme (2008) and NHMRC (Project Grants #568729, #566843, and #628723).