Journal article

Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium

Andrei I Ivanov, Cheryl Young, Kyle Den Beste, Christopher T Capaldo, Patrick O Humbert, Patrick Brennwald, Charles A Parkos, Asma Nusrat

American Journal of Pathology | AMER SOC INVESTIGATIVE PATHOLOGY, INC | Published : 2010

Abstract

Formation of the epithelial barrier and apico-basal cell polarity represent two characteristics and mutually dependent features of differentiated epithelial monolayers. They are controlled by special adhesive structures, tight junctions (TJs), and polarity protein complexes that define the apical and the basolateral plasma membrane. The functional interplay between TJs and polarity complexes remains poorly understood. We investigated the role of Scribble, a basolateral polarity protein and known tumor suppressor, in regulating TJs in human intestinal epithelium. Scribble was enriched at TJs in T84 and SK-CO15 intestinal epithelial cell monolayers and sections of normal human colonic mucosa. ..

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Grants

Awarded by National Institutes of Health


Awarded by Emory epithelial pathobiology research development


Awarded by Medical Scientists Training Program


Awarded by NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES


Awarded by NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES


Funding Acknowledgements

Supported by National Institutes of Health grants DK 55679 (to A. N.), DK 61379 and DK 72564 (to C.A.P.), Emory epithelial pathobiology research development grant R24DK 064399, and Medical Scientists Training Program T32 GM008169-21 (to C. Y.).