Construction of a genetic classifier for ASD using gene pathway analysis

Abstract

A number of genetic investigations in autism spectrum disorders (ASD) have identified single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) that are associated with this neurodevelopmental disorder. However, as research progresses the evidence points to these genetic alterations likely being confined to specific families or populations with their penetrance in larger populations being somewhat lower. This has led researchers to postulate that the genetics of ASD may consist of an additive collection of common genetic variations that when considered in combination with each other are able to explain more of the heritability of the disorder. In addition to taking a more global..