Journal article
Oxidative & nitrosative stress in depression: Why so much stress?
S Moylan, M Berk, OM Dean, Y Samuni, LJ Williams, A O'Neil, AC Hayley, JA Pasco, G Anderson, FN Jacka, M Maes
Neuroscience and Biobehavioral Reviews | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2014
Abstract
Many studies support a crucial role for oxidative & nitrosative stress (O&NS) in the pathophysiology of unipolar and bipolar depression. These disorders are characterized inter alia by lowered antioxidant defenses, including: lower levels of zinc, coenzyme Q10, vitamin E and glutathione increased lipid peroxidation; damage to proteins, DNA and mitochondria; secondary autoimmune responses directed against redox modified nitrosylated proteins and oxidative specific epitopes. This review examines and details a model through which a complex series of environmental factors and biological pathways contribute to increased redox signaling and consequently increased O&NS in mood disorders. This multi..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
MB has received Grant/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary Health, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Novartis, Mayne Pharma, Servier and Woolworths, has been a speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Merck, Pfizer, Sanofi Synthelabo, Servier, Solvay and Wyeth, and served as a consultant to Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck Merck and Servier. MB, AO, FNJ have received funding from Meat and Livestock, Australia. JAP has received Grant/Research support from the NHMRC, Perpetual, Amgen, BUPA Foundation and Arthritis Australia and has received speaker fees from Amgen and Sanofi Aventis. OMD has received Grant support from the Brain and Behavior Foundation, Simons Autism Foundation, Stanley Medical Research Institute, Lilly, NHMRC, an Alfred Deakin Postdoctoral Research Fellowship and an ASBD/Servier grant. LW has received Grant/Research support from Eli Lilly, Pfizer, The University of Melbourne, Deakin University and the NHMRC.