Journal article
The more you look, the more you find: Effects of hepatitis C virus testing interval on reinfection incidence and clearance and implications for future vaccine study design
P Vickerman, J Grebely, GJ Dore, R Sacks-Davis, K Page, DL Thomas, WO Osburn, AL Cox, CK Aitken, M Hickman, M Hellard
Journal of Infectious Diseases | Published : 2012
Abstract
Introduction. Studies have explored whether spontaneous clearance of hepatitis C virus (HCV) infection decreases the likelihood of reinfection or increases the probability of clearance. This analysis investigates whether the conflicting findings from these studies could be due to differences in frequency of HCV RNA testing. Methods. A model simulated the dynamics of HCV reinfection and clearance among a cohort of injection drug users. For different reinfection incidence and clearance rates, the model evaluated the accuracy of epidemiological studies that used different HCV testing frequencies.Results. Experimental estimates for the reinfection incidence and clearance probability will be accu..
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Awarded by National Institutes of Health
Funding Acknowledgements
P. V. is funded by a UK Medical Research Council New Investigators Award (G0701627), G. D. is supported by a National Health and Medical Research Council (NHMRC) Practitioner Fellowship, J. G. is funded by a NHMRC Career Development Fellowship, R. S. D. is funded by a NHMRC postgraduate scholarship and a Centre for Research Excellence in Injecting Drug Use top-up scholarship, and M. Hellard is supported by a NHMRC Senior Research Fellowship. C. A. is funded by the Burnet Institute, W. O. and A. C. are funded by the US National Institutes of Health (NIH; grant U19AI088791), D. T. is funded by DAR01016078 and K. P. is supported by the NIH (grants 5R01DA016017 and 1R01DA0310560 1A1) and the University of California, San Francisco, Liver Center (P30 DK026743).