Serotonin(2A) receptors are reduced in the planum temporale from subjects with schizophrenia

Abstract

[3H] ketanserin binding to 5HT(2A) receptors was measured in the left planum temporale (sensory speech cortex) from schizophrenic and non-schizophrenic (control) subjects using both particulate membranes and tissue sections. There was a significant decrease in the affinity of [3H] ketanserin binding to particulate membranes from schizophrenic subjects who were treated with phenothiazines up to death. Adding 2 nM chlorpromazine to brain tissue from control subjects caused a similar decrease in the affinity of [3H] ketanserin binding to particulate membranes. This suggests that the decrease in affinity observed in the phenothiazine-treated subjects was due to residual drugs. In addition, there..