Journal article
A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase
H Hong, JB Spencer, JL Porter, PF Leadlay, T Stinear
Chembiochem | WILEY-V C H VERLAG GMBH | Published : 2005
Abstract
New analogues of the toxin mycolactone have been identified in a pathogenic Chinese strain of Mycobacterium ulcerans. They possess an extra methyl group at C2′ (shown in red) compared to mycolactone A as a result of the recruitment of a single catalytic domain of altered specificity in the mycolactone polyketide synthase. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.