Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

TP Stinear; T Seemann; PF Harrison; GA Jenkin; JK Davies; PDR Johnson; Z Abdellah; C Arrowsmith; T Chillingworth; C Churcher; K Clarke; A Cronin; P Davis; I Goodhead; N Holroyd; K Jagels; A Lord; S Moule; K Mungall; H Norbertczak; MA Quail; E Rabbinowitsch; D Walker; B White; S Whitehead; PLC Small; R Brosch; L Ramakrishnan; MA Fischbach; J Parkhill; ST Cole

Journal article

Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis

TP Stinear, T Seemann, PF Harrison, GA Jenkin, JK Davies, PDR Johnson, Z Abdellah, C Arrowsmith, T Chillingworth, C Churcher, K Clarke, A Cronin, P Davis, I Goodhead, N Holroyd, K Jagels, A Lord, S Moule, K Mungall, H Norbertczak Show all

Genome Research | Published : 2008

DOI: 10.1101/gr.075069.107

Abstract

Mycobacterium marinum, a ubiquitous pathogen of fish and amphibia, is a near relative of Mycobacterium tuberculosis, the etiologic agent of tuberculosis in humans. The genome of the M strain of M. marinum comprises a 6,636,827-bp circular chromosome with 5424 CDS, 10 prophages, and a 23-kb mercury-resistance plasmid. Prominent features are the very large number of genes (57) encoding polyketide synthases (PKSs) and nonribosomal peptide synthases (NRPSs) and the most extensive repertoire yet reported of the mycobacteria-restricted PE and PPE proteins, and related-ESX secretion systems. Some of the NRPS genes comprise a novel family and seem to have been acquired horizontally. M. marinum is us..

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