Journal article
Incidence of transformation to aggressive lymphoma in limited-stage follicular lymphoma treated with radiotherapy
P Bains, A Al Tourah, BA Campbell, T Pickles, RD Gascoyne, JM Connors, KJ Savage
Annals of Oncology | Published : 2013
Abstract
Background: The established treatment of limited-stage follicular lymphoma is radiotherapy (RT). There is an inherent risk of transformation of follicular lymphoma to aggressive lymphoma; however, the frequency and impact on the outcome are unknown in limited-stage patients. Materials and methods: We identified 237 patients with limited-stage follicular lymphoma treated with curative intent RT. Cases were reviewed to determine the frequency of transformation and subsequent survival. Results: With a median follow-up of 7.4 years, the 10-year risk of transformation was 18.5%. With a median follow-up after transformation of 4.7 years, the 3-year post-transformation progression-free survival (PF..
View full abstractGrants
Funding Acknowledgements
This work was supported by National Cancer Institute grant CA62006 (Connecticut); National Cancer Institute grants R01 CA92153 and P50 CA97274 (Mayo); National Institute of Health grants CA45614, CA89745, CA87014, CA143947 and CA150037 (UCSF); National Cancer Institute grant CA50850 (Los Angeles); the Canadian Cancer Society through the National Cancer Institute of Canada, the Canadian Institutes for Health Research and the Chan Sisters Foundation (British Columbia); Leukaemia and Lymphoma Research (UK); the National Research Council (CNR) Applied Project 'Clinical Applications of Oncological Research' and the Italian Association for Cancer Research (Northern Italy); the European Community (Europe Against Cancer Programme), the Lega Italiana per la Lotta Contro i Tumori and Italian Association for Research on Cancer (Italy); Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports, Culture and Technology of Japan (HERPACC2). The study sponsors had no involvement in study design; collection, analysis, and interpretation of data; writing of the report; and the decision to submit the paper for publication. EK is supported by the Leukaemia and Lymphoma Research, UK.