Journal article

ANALYSIS OF HEMATOPOIESIS IN MAX-41 TRANSGENIC MICE THAT EXHIBIT SUSTAINED ELEVATIONS OF BLOOD GRANULOCYTES AND MONOCYTES

D METCALF, GJ LINDEMAN, NA NICOLA

BLOOD | W B SAUNDERS CO | Published : 1995

Abstract

An unusual mouse line (max 41) that carries an inserted transgene encoding the nuclear transcription factor, Max, exhibits a 50- to 60-fold elevation of blood neutrophils and a 10-fold elevation of blood monocytes. Analysis showed that these elevated levels of blood cells were sustained incrementally by a sevenfold increase in mature neutrophils in the bone marrow and spleen and a fourfold increase in granulocyte-committed progenitor cells with normal turnover times for mature neutrophils and monocytes in the marrow and blood. the progenitor cells were not autonomous and exhibited a normal quantitative responsiveness to stimulation in vitro by the four colony-stimulating factors. A consisten..

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