Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C

HL Tillmann; K Patel; AJ Muir; CD Guy; JH Li; XQ Lao; A Thompson; PJ Clark; SD Gardner; JG McHutchison; JJ McCarthy

Journal article

Beneficial IL28B genotype associated with lower frequency of hepatic steatosis in patients with chronic hepatitis C

HL Tillmann, K Patel, AJ Muir, CD Guy, JH Li, XQ Lao, A Thompson, PJ Clark, SD Gardner, JG McHutchison, JJ McCarthy

Journal of Hepatology | Published : 2011

DOI: 10.1016/j.jhep.2011.03.015

Abstract

Background & Aims: IL28B polymorphisms have been associated with both treatment induced and spontaneous clearance of hepatitis C virus (HCV). We previously found that LDL cholesterol levels were higher in chronic hepatitis C (CHC) patients with the CC genotype at the rs12979860 polymorphism, located proximal to the IL28 gene. Here we analyzed the association of steatosis with IL28B genotype in treatment naïve patients with CHC. Methods: Two independent cohorts of 145 genotype 1 infected patients from an antifibrotic study and 180 genotype 1 patients from Duke were analyzed for the presence and severity of steatosis in relation to the rs12979860 polymorphism at the IL28B locus. TaqMan assay b..

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University of Melbourne Researchers

Alexander Thompson Author

Grants

Awarded by National Institutes of Health

Funding Acknowledgements

This study was funded in part by a generous grant from the David H. Murdock Institute for Business and Culture via the M.U.R.D.O.C.K. Study and award 1 UL<INF>1</INF> RR024128-01 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) and NIH Roadmap for Medical Research, and its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCRR or NIH.