Journal article
Structure of the N-terminal domain of human thioredoxin-interacting protein
G Polekhina, DB Ascher, SF Kok, S Beckham, M Wilce, M Waltham
Acta Crystallographica Section D Biological Crystallography | INT UNION CRYSTALLOGRAPHY | Published : 2013
Abstract
Thioredoxin-interacting protein (TXNIP) is one of the six known α-arrestins and has recently received considerable attention owing to its involvement in redox signalling and metabolism. Various stress stimuli such as high glucose, heat shock, UV, H2O2 and mechanical stress among others robustly induce the expression of TXNIP, resulting in the sequestration and inactivation of thioredoxin, which in turn leads to cellular oxidative stress. While TXNIP is the only α-arrestin known to bind thioredoxin, TXNIP and two other α-arrestins, Arrdc4 and Arrdc3, have been implicated in metabolism. Furthermore, owing to its roles in the pathologies of diabetes and cardiovascular disease, TXNIP is consider..
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
Awarded by NHMRC
Funding Acknowledgements
GP was the recipient of a Career Development Award (502724) from the National Health and Medical Research Council (NHMRC) of Australia. This work was supported by a grant (448305) from NHMRC to GP and Mark Waltham. Matthew Wilce is an NHMRC Senior Research Fellow and SB is supported by an NHMRC grant. We acknowledge the funding for MALS equipment from the Australian Research Council and the Victorian Government's Operational Infrastructure Support Program. DBA was an Australian Postgraduate Award Scholar as well as a recipient of a St Vincent's Institute Foundation Scholarship sponsored by Colin North and Major Engineering. This research was undertaken at the Australian Synchrotron, Victoria, Australia. We appreciate the support provided by all staff at the Australian Synchrotron during our visits. We would also like to acknowledge the staff, and particularly Dr Janet Newman, at the Bio21 Collaborative Crystallographic Centre at CSIRO Molecular and Health Technologies, Parkville, Melbourne. We thank Frances Cribbin for help with the manuscript.