Journal article
Abnormal structure and function of the esophagogastric junction and proximal stomach in gastroesophageal reflux disease
J Curcic, S Roy, A Schwizer, E Kaufman, Z Forras-Kaufman, D Menne, GS Hebbard, R Treier, P Boesiger, A Steingoetter, M Fried, W Schwizer, A Pal, M Fox
American Journal of Gastroenterology | Published : 2014
DOI: 10.1038/ajg.2014.25
Abstract
Objectives: This study applies concurrent magnetic resonance imaging (MRI) and high-resolution manometry (HRM) to test the hypothesis that structural factors involved in reflux protection, in particular, the acute insertion angle of the esophagus into the stomach, are impaired in gastroesophageal reflux disease (GERD) patients. Methods: A total of 24 healthy volunteers and 24 patients with mild-moderate GERD ingested a test meal. Three-dimensional models of the esophagogastric junction (EGJ) were reconstructed from MRI images. Measurements of the esophagogastric insertion angle, gastric orientation, and volume change were obtained. Esophageal function was assessed by HRM. Number of reflux ev..
View full abstractGrants
Awarded by Council of Scientific and Industrial Research, India
Awarded by Royal Society International Exchange Grant
Funding Acknowledgements
This investigator-led research was supported by an unrestricted research grant from Astra Zeneca (Molndal, Sweden). The authors retained control of the data and the information submitted for publication. Additional financial support was provided by the Baugarten Foundation of the University of Zurich and the Zurich Centre for Integrative Human Physiology. A.P. was supported by initiation grant from Indian Institute of Technology Kanpur, and Council of Scientific and Industrial Research, India (Scheme number: 37(1287)/07/EMR-II). The collaboration between M.F. and A.P. is supported by a Royal Society International Exchange Grant (#2011/0729032650226750).