Journal article
Shape analysis of the corpus callosum in Alzheimer's disease and frontotemporal lobar degeneration subtypes
M Walterfang, E Luders, JCL Looi, P Rajagopalan, D Velakoulis, PM Thompson, O Lindberg, P Östberg, LE Nordin, L Svensson, LO Wahlund
Journal of Alzheimer S Disease | IOS PRESS | Published : 2014
DOI: 10.3233/JAD-131853
Abstract
Morphology of the corpus callosum is a useful biomarker of neuronal loss, as different patterns of cortical atrophy help to distinguish between dementias such as Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD). We used a sophisticated morphometric analysis of the corpus callosum in FTLD subtypes including frontotemporal dementia (FTD), semantic dementia (SD), and progressive non-fluent aphasia (PNFA), and compared them to AD patients and 27 matched controls. FTLD patient subgroups diverged in their callosal morphology profiles, with FTD patients showing marked widespread differences, PNFA patients with differences largely in the anterior half of the callosum, and SD pat..
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Awarded by National Institute of Biomedical Imaging and Bioengineering
Funding Acknowledgements
This research has made use of the SMILE medical imaging laboratory at Karolinska University Hospital, Stockholm, Sweden. Dr. Eva Orndahl, formerly of the Karolinska University Hospital, contributed to a previous poster version of this paper. A/Prof J.C.L. Looi self-funded travel costs to assist in coordination of this research in Australia, USA, and Sweden as part of the Australian United States Scandinavian Imaging Exchange (AUSSIE). E.L., P.R., and P.T. are funded by grants from the U.S. National Institutes of Health, including a P41 resource grant from the NIBIB.