Journal article
Human papillomavirus, smoking status and outcomes in tonsillar squamous cell carcinoma
AM Hong, A Martin, M Chatfield, D Jones, M Zhang, B Armstrong, CS Lee, G Harnett, C Milross, J Clark, M Elliott, R Smee, J Corry, C Liu, S Porceddu, G Rees, B Rose
International Journal of Cancer | Published : 2013
DOI: 10.1002/ijc.27956
Abstract
It is now clear that the two separate entitles of tonsillar cancer, HPV induced and non-HPV induced (smoking induced), have significantly different presenting stage and outcomes. A significant proportion of patients with human papillomavirus positive tonsillar cancer have had exposure to smoking. We examined the combined effect of human papillomavirus and smoking on the outcomes and determined whether smoking can modify the beneficial effect of human papillomavirus. A total of 403 patients from nine centers were followed up for recurrence or death for a median of 38 months. Determinants of the rate of loco-regional recurrence, death from tonsillar cancer and overall survival were modeled usi..
View full abstractGrants
Funding Acknowledgements
Grant sponsors: Diagnostics and Technology Branch of the Australian Government Department of Health and Ageing with the support of Cancer Australia, The Cure Cancer Foundation Australia and Sydney Head and Neck Cancer Institute, Royal Prince Alfred Hospital