An automated voxelized dosimetry tool for radionuclide therapy based on serial quantitative SPECT/CT imaging
Price A Jackson, Jean-Mathieu Beauregard, Michael S Hofman, Tomas Kron, Annette Hogg, Rodney J Hicks
MEDICAL PHYSICS | WILEY | Published : 2013
PURPOSE: To create an accurate map of the distribution of radiation dose deposition in healthy and target tissues during radionuclide therapy. METHODS: Serial quantitative SPECT∕CT images were acquired at 4, 24, and 72 h for 28 (177)Lu-octreotate peptide receptor radionuclide therapy (PRRT) administrations in 17 patients with advanced neuroendocrine tumors. Deformable image registration was combined with an in-house programming algorithm to interpolate pharmacokinetic uptake and clearance at a voxel level. The resultant cumulated activity image series are comprised of values representing the total number of decays within each voxel's volume. For PRRT, cumulated activity was translated to abs..View full abstract
This work was funded by support of the Victorian government through the Victorian Cancer Agency Lutetium Therapy grant for the Molecular Imaging and Targeted Therapeutics group at the Peter Mac Callum Cancer Centre.