Relationships among liver and kidney volumes, lean body mass and drug clearance

Abstract

Aims. To determine whether lean body mass (LBM), a possible surrogate of liver and kidney volumes, correlates with hepatic and renal drug clearances. Methods. Twenty-one disease-free patients with a history of cancer and with normal hepatic and renal function were studied. Salivary pharmacokinetics of oral antipyrine (1200 mg) and 24 h creatinine clearance were determined following the determination of LBM by dual energy X-ray absorptiometry and the determination of liver and kidney volumes by helical CT scanning. Results. Liver volume correlated with LBM (r2 = 0.21, P = 0.04), body surface area (BSA) (r2 = 0.54, P < 0.001), and total body weight (TBW) (r2 = 0.61, P < 0.001). Kidney volume c..