Effects of renal denervation on regional hemodynamics and kidney function in experimental hyperdynamic sepsis

P Calzavacca; M Bailey; E Velkoska; LM Burrell; R Ramchandra; R Bellomo; CN May

Journal article

Effects of renal denervation on regional hemodynamics and kidney function in experimental hyperdynamic sepsis

P Calzavacca, M Bailey, E Velkoska, LM Burrell, R Ramchandra, R Bellomo, CN May

Critical Care Medicine | Published : 2014

DOI: 10.1097/CCM.0000000000000302

Abstract

OBJECTIVE: To determine the influence of the renal sympathetic nerves on the pathogenesis of septic acute kidney injury. DESIGN: Interventional control study to determine the effects of renal denervation in ovine hyperdynamic sepsis. SETTING: Research Institute. SUBJECTS: Twenty-four adult Merino ewes. INTERVENTIONS: The effects of infusion of angiotensin II and norepinephrine and induction of hyperdynamic sepsis by administration of live Escherichia coli were examined in control sheep and in sheep at 2 weeks after bilateral renal denervation (n = 10/group). MEASUREMENTS AND MAIN RESULTS: Systemic hemodynamics and renal function were measured in conscious sheep instrumented with flow probes ..

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University of Melbourne Researchers

Louise Burrell Author

Clive May Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC), Australia

Awarded by NHMRC

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

[ "National Health and Medical Research Council (NHMRC), Australia (1050672 and 566947), and by funding from the Victorian Government Operational Infrastructure Support Grant.", "Dr. Calzavacca is employed by Melbourne university postgraduate scholarship and supported by an International Postgraduate Student Scholarship from the University of Melbourne. Dr. Ramchandra is employed by NHMRC/National Heart Foundation Fellowship and received grant support from NHMRC. Dr. May received support for travel (travel and accommodation paid to give invited talks at conferences). He is employed by the Florey Institute of Neuroscience and received support for article research from NHMRC (566819). His institution received grant support from NHMRC. The remaining authors have disclosed that they do not have any potential conflicts of interest." ]