Transient Systemic Inflammation Does Not Alter the Induction of Tolerance to Gastric Autoantigens by Migratory Dendritic Cells
Dorothee Bourges, Ellen M Ross, Stacey Allen, Simon Read, Fiona J Houghton, Sammy Bedoui, Louis Boon, Paul A Gleeson, Ian R van Driel
JOURNAL OF IMMUNOLOGY | AMER ASSOC IMMUNOLOGISTS | Published : 2014
It has been proposed that activation of dendritic cells (DCs) presenting self-antigens during inflammation may lead to activation of autoreactive T cells and the development of autoimmunity. To test this hypothesis, we examined the presentation of the autoantigen recognized in autoimmune gastritis, gastric H(+)/K(+) ATPase, which is naturally expressed in the stomach and is constitutively presented in the stomach-draining lymph nodes. Systemic administration to mice of the TLR9 agonist CpG DNA, agonist anti-CD40 Ab, or TLR4 agonist LPS all failed to abrogate the process of peripheral clonal deletion of H(+)/K(+) ATPase-specific CD4 T cells or promote the development of autoimmune gastritis. ..View full abstract
This work was supported by the National Health and Medical Research Council of Australia.