Journal article
Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland
NJ Godde, JM Sheridan, LK Smith, HB Pearson, KL Britt, RC Galea, LL Yates, JE Visvader, PO Humbert
Plos Genetics | Published : 2014
Abstract
Polarity coordinates cell movement, differentiation, proliferation and apoptosis to build and maintain complex epithelial tissues such as the mammary gland. Loss of polarity and the deregulation of these processes are critical events in malignant progression but precisely how and at which stage polarity loss impacts on mammary development and tumourigenesis is unclear. Scrib is a core polarity regulator and tumour suppressor gene however to date our understanding of Scrib function in the mammary gland has been limited to cell culture and transplantation studies of cell lines. Utilizing a conditional mouse model of Scrib loss we report for the first time that Scrib is essential for mammary du..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This work was supported by a Victorian State Government and Operational Infrastructure Support Grant (JEV), the Cancer Council Victoria (Project Grant to POH) and the Australian National Health and Medical Research Council (Australia Fellowship to JEV; Biomedical Career Development Award to POH, NHMRC 509336) and AICR 07-0544 to POH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.