Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Nathan J Godde; Julie M Sheridan; Lorey K Smith; Helen B Pearson; Kara L Britt; Ryan C Galea; Laura L Yates; Jane E Visvader; Patrick O Humbert

Journal article

Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Nathan J Godde, Julie M Sheridan, Lorey K Smith, Helen B Pearson, Kara L Britt, Ryan C Galea, Laura L Yates, Jane E Visvader, Patrick O Humbert

PLOS GENETICS | PUBLIC LIBRARY SCIENCE | Published : 2014

DOI: 10.1371/journal.pgen.1004323

University of Melbourne Researchers

Kara Britt Author The Sir Peter MacCallum Department of Oncology

Julie Sheridan Author Medical Biology (W.E.H.I.)

Patrick Humbert Author Biochemistry and Molecular Biology

Jane Visvader Author Medical Biology (W.E.H.I.)

Related Projects (1)

The Function Of Polarity Genes In Cancer

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regula..

Grants

Awarded by Australian National Health and Medical Research Council

Awarded by AICR

Funding Acknowledgements

This work was supported by a Victorian State Government and Operational Infrastructure Support Grant (JEV), the Cancer Council Victoria (Project Grant to POH) and the Australian National Health and Medical Research Council (Australia Fellowship to JEV; Biomedical Career Development Award to POH, NHMRC 509336) and AICR 07-0544 to POH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.