Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals

CLV Westhorpe; A Maisa; T Spelman; JF Hoy; EM Dewar; S Karapanagiotidis; AC Hearps; WJ Cheng; J Trevillyan; SR Lewin; D Sviridov; JH Elliott; A Jaworowski; AM Dart; SM Crowe

Journal article

Associations between surface markers on blood monocytes and carotid atherosclerosis in HIV-positive individuals

CLV Westhorpe, A Maisa, T Spelman, JF Hoy, EM Dewar, S Karapanagiotidis, AC Hearps, WJ Cheng, J Trevillyan, SR Lewin, D Sviridov, JH Elliott, A Jaworowski, AM Dart, SM Crowe

Immunology and Cell Biology | WILEY | Published : 2014

DOI: 10.1038/icb.2013.84

Abstract

Chronic HIV infection is associated with increased risk of cardiovascular disease (CVD), including in patients with virological suppression. Persistent innate immune activation may contribute to the development of CVD via activation of monocytes in these patients. We investigated whether changes in monocyte phenotype predict subclinical atherosclerosis in virologically suppressed HIV-positive individuals with low cardiovascular risk. We enroled 51 virologically suppressed HIV-positive individuals not receiving protease inhibitors or statins and 49 age-matched uninfected controls in this study. Carotid artery intima-media thickness (cIMT) was used as a surrogate marker for CVD, and traditiona..

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University of Melbourne Researchers

Timothy Spelman Author

Janine Trevillyan Author

Sharon Lewin Author

Related Projects (1)

IMPROVED HEALTH OUTCOMES FOR PEOPLE LIVING WITH HIV

Despite the success of antiviral therapy for HIV infection, HIV cannot be cured and treatment is life long. In addition, there are complicat..

Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)

Funding Acknowledgements

We would like to acknowledge the Clinical Research Unit nursing staff at The Alfred Hospital for study participant recruitment as well as the study participants themselves. This work was funded by the Australian Centre for HIV and Hepatitis Research (ACH<SUP>2</SUP>) and by the National Health and Medical Research Council of Australia (NHMRC) through project grant 543137 and its Independent Research Institute Infrastructure Support Scheme. We gratefully acknowledge the Victorian Operational Infrastructure Support Program. AM is supported by a fellowship within the Postdoctoral Programme of the German Academic Exchange Service (DAAD) and by an Occupational Trainee Scholarship of the Burnet Institute. AMD is a recipient of an NHMRC Senior Principal Research Fellowship. SMC is a recipient of an NHMRC Principal Research Fellowship.