Journal article
The end of AIDS: HIV infection as a chronic disease
SG Deeks, SR Lewin, DV Havlir
Lancet | Published : 2013
Abstract
The success of antiretroviral therapy has led some people to now ask whether the end of AIDS is possible. For patients who are motivated to take therapy and who have access to lifelong treatment, AIDS-related illnesses are no longer the primary threat, but a new set of HIV-associated complications have emerged, resulting in a novel chronic disease that for many will span several decades of life. Treatment does not fully restore immune health; as a result, several infl ammation-associated or immunodefi ciency complications such as cardiovascular disease and cancer are increasing in importance. Cumulative toxic eff ects from exposure to antiretroviral drugs for decades can cause clinically-rel..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
SGD was supported by the National Institute of Allergy and Infectious Diseases (NIAID; K24 AI069994), the DARE: Delaney AIDS Research Enterprise (U19AI096109), and the University of California, San Francisco (UCSF)/Gladstone Center for AIDS Research (CFAR; P30 AI027763). SRL is a National Health and Medical Research Council (NHMRC) of Australia Practitioner Fellow and is supported by DARE: Delaney AIDS Research Enterprise (U19AI096109) and NIAID (1R56AI095073-01A1). SRL gratefully acknowledges the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. DVH was supported by NIAID (A151982) and the UCSF/Gladstone CFAR (A1027763). We acknowledge the support of John Carroll and Warner Greene of the Gladstone Institute of Virology and Immunology for assistance with the figures.