Journal article

The Role of Wnt Signaling in the Development of Alzheimer's Disease: A Potential Therapeutic Target?

Wenbin Wan, Shijin Xia, Bill Kalionis, Lumei Liu, Yaming Li

BIOMED RESEARCH INTERNATIONAL | HINDAWI LTD | Published : 2014

Abstract

Accumulating evidence supports a key role for Wnt signaling in the development of the central nervous system (CNS) during embryonic development and in the regulation of the structure and function of the adult brain. Alzheimer's disease (AD) is the most common form of senile dementia, which is characterized by β -amyloid (A β ) deposition in specific brain regions. However, the molecular mechanism underlying AD pathology remains elusive. Dysfunctional Wnt signaling is associated with several diseases such as epilepsy, cancer, metabolic disease, and AD. Increasing evidence suggests that downregulation of Wnt signaling, induced by A β , is associated with disease progression of AD. More importa..

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Grants

Awarded by National Natural Science Foundation of China


Awarded by Shanghai Committee of Science and Technology, China


Funding Acknowledgements

This work was supported by National Natural Science Foundation of China (Grant nos. 31171129 and 81270115) and Shanghai Committee of Science and Technology, China (Grant no. 12401904500).