Journal article

EVALUATION OF A MORPHOLINOTHIOLPORPHYRIN FOR USE IN PHOTODYNAMIC THERAPY

KW WOODBURN, JS HILL, S STYLLI, AH KAYE, JA REISS, DR PHILLIPS

BRITISH JOURNAL OF CANCER | STOCKTON PRESS | Published : 1994

Abstract

The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific 'photopotent' subcellular sites.