Journal article
Evaluation of a morpholinothiolporphyrin for use in photodynamic therapy
KW Woodburn, JS Hill, S Stylli, AH Kaye, JA Reiss, DR Phillips
British Journal of Cancer | STOCKTON PRESS | Published : 1994
DOI: 10.1038/bjc.1994.316
Abstract
The photonecrotic effectiveness of a morpholinothiolporphyrin derived from haematoporphyrin was measured in an animal model of cerebral glioma. The dose administered was 20 mg kg-1 and the laser dose varied from 0 to 200 J cm-2. The tumour necrosis was at least as good as that of HpD, and this therapeutic response may be attributed to the targeting of specific ‘photopotent’ subcellular sites. © Macmillan Press Ltd., 1994.