Journal article
A case-control study of the role of human papillomavirus in oesophageal squamous cell carcinoma in Australia
SS Liyanage, E Segelov, A Malik, SM Garland, SN Tabrizi, E Cummins, H Seale, B Rahman, A Moa, AP Barbour, PJ Crowe, CR Macintyre
Journal of Oncology | Published : 2014
DOI: 10.1155/2014/236482
Abstract
Objective. We investigate the prevalence of human papillomavirus (HPV) in oesophageal squamous cell carcinoma (OSCC) tissues compared to oesophageal tissue from healthy controls, in an Australian cohort. Methods. We conducted a hospital-based case-control study of 99 patients with OSCC and 100 healthy controls to examine the presence of HPV DNA. Paraffin tissues were tested using the PapType high-risk HPV detection and genotyping kit and with INNO-LiPA HPV Genotyping Extra. The biopsy samples were tested for HPV using a PCR-ELISA method based on the L1 consensus primer set PGMY09-PGMY11. Results. HPV DNA of the oncogenic genotype 16 was detected in 1/99 case specimens, a rate of 1010 per 100..
View full abstractGrants
Awarded by National Science Foundation
Funding Acknowledgements
Suzanne M. Garland has received advisory board fees and grant support from CSL and GlaxoSmithKline and lecture fees from Merck, GSK, and Sanofi Pasteur; in addition, she has received funding through her institution to conduct HPV vaccine studies for MSD and GSK. She is a member of the Merck Global Advisory Board as well as the Merck Scientific Advisory Committee for HPV. C. Raina MacIntyre has received funds from GSK and Merck for investigator-driven research on several vaccines. Holly Seale currently holds a National Health and Medical Research Council (NHMRC) Training Fellowship (1012631 - Australian Based Public Health Fellowship).